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KMID : 0613820110210070985
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Journal of Life Science
2011 Volume.21 No. 7 p.985 ~ p.991
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The Effects of Treadmill Training on Neurotrophins and Immediately Early Protein in Obese Rats
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Woo Jin-Hee
Shin Ki-Ok
Yeo Nam-Heoh
Park So-Young
Kang Sung-Hwun
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Abstract
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The purpose of this study was to investigate the biological effect of obesity-induced oxidative damage on neurogenesis and early protein expression. Obesity was induced I thirty 4-week old male Sprague-Dawley rats through a high fat diet for 15 weeks. After one week of environmental adaptation, the rats were divided into 2 groups: high fat diet sedentary group (HDS, n=15) and high fat diet training group (HDT, n=15). Exercise training was performed 5 times a week for 8 weeks, with mild-intensity treadmill running for weeks 1-4 and moderate-intensity treadmill running for weeks 5-8. After the 8 week training period, we analyzed lipid profiles, serum 8-hydroxyguanosine (8-OHdG), liver tissue malondialdehyde (MDA) related to oxidative damage factors, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), c-fos, c-jun, and extracellular signal regulated kinase (Erk) in the hippocampus. The results of this study are as follows. There were differences between HDS and HDT in triglyceride (TG) and total cholesterol (TC) (p＜0.05). In high density lipoprotein (HDL-c), the HDT was higher than HDS after treadmill training (p＜0.05). In 8-OHdG, the HDT was lower than HDS after treadmill training (p＜0.05). Genetic expressions of c-jun, BDNF and MDA in the HDT were higher than in the HDS after treadmill training in hippocampus (p＜0.05). Therefore, we conclude that 8 weeks of treadmill training can improve imbalanced lipid profiles, reduce oxidative damage, and activate neurogenesis in obese rats.
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KEYWORD
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Neurogenesis, 8-OHdG, BDNF, c-fos, c-jun
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